Epithalon, sometimes spelled Epitalon, is a synthetic version of the polypeptide Epithalamin. Studies have shown that Epithalon may posses the potential to increase the production of telomerase, an enzyme in the cells that plays a central role in cell fate and aging.
A study in mice suggests that premature aging can be reversed by reactivating telomerase. Mice engineered to lack the enzyme had become prematurely decrepit.
However, when telomerase was replaced, they bounced back to health.
Epithalon is a synthetic version of the polypeptide Epithalamin, which has been shown to potentially increase lifespan in rats and mice. A human study found that Epithalamin-treated patients registered a 1.6-1.8-fold mortality decrease compared to the control group.
Epithalon was first discovered in Russia in the 1980s. Professor Vladimir Khavinson, who discovered it, had previously extracted epithalamin from bovine pineal glands.
The difficulty of extracting the natural polypeptide in large amounts led him to create a synthetic version.
Research shows that Epitalon reproduces the effects of Epithalamin. In particular, Epitalon prolongs the lifespan of mice and fruit flies. This synthetic peptide also restores the circadian rhythms of melatonin and cortisol production in old rhesus monkeys.