Methandionex 25 is an orally applicable steroid that has a great effect on protein metabolism. It is a derivative of testosterone and has a very strong anabolic and androgenic properties. It induces a positive nitrogen balance, supports the build up of protein, and skeletal muscle mass. Methandionex also induces an improved sense of well-being. Methandionex 25 is one of the most highly effective mass building steroids ever created. It is known that 10 mg of the Methandionex 25 was enough for full androgen replacement in a man, and this dose increased androgen anabolic activity roughly 5 times over normal. Despite this, many athletes take 50-100 mg daily.
It would appear that over 50 mg/day, there is a point of diminishing return. However, not all effects of Methandionex are positive. One of the most known side effects of Methandienone overuse is on the liver. However, these effects are short lived and liver values return to normal. Some of the other effects are estrogenic effects, the risk for which is minimized if Methandienone use is stacking with an anti-estrogen.
This side effects may include gynecomastia, salt and water retention, high blood pressure, oily skin, facial hair and acne (though not very severe). As a result of the mild androgenic constituent of Methandienone high doses may also lead to some hair fall in the male pattern. It may also lead to changes in disposition like more aggression and irritability or in some cases the opposite of it, causing the individual to go into depression. However, most of the effects are thought to be non-androgen receptor mediated because Methandionex is a very weak Androgen Receptor binder. This also proves the low aromatase activity of Methandienone. Methandienone's users do not have to worry about sudden decrease in their natural testosterone production since the side effects are not considered to be androgen receptor dependent.