A recent study on diet-induced obese mice treated with SR9009 and SR9011 (i.e., two times a day for 30 days) have been reported to display decreased fat mass and markedly improved dyslipidemia and hyperglycemia.
The activation of REV-ERB leads to the enhancement of circadian rhythm observed in mice. This affects behaviour, sleep cycle and some functions related to increment in energy production.
Another study found that mice administered SR9009 could run longer distances and for longer durations than vehicle-treated mice. This research compound also increased the number of total and active mitochondria.