Tamoxifen Citrate is a prodrug that is metabolized to its active metabolite, N-desmethyl-tamoxifen (endoxifen). Endoxifen has a higher binding affinity for the estrogen receptor than tamoxifen and is a more potent inhibitor of estrogen receptor-mediated gene transcription.
Tamoxifen Citrate is an antagonist of the estrogen receptor in breast tissue. Like estrogen, it binds to the estrogen receptor, activating the receptor and stimulating gene transcription. In breast tissue, this can lead to cell proliferation, but in other tissues, Tamoxifen Citrate activates the receptor and leads to cell growth arrest, cell differentiation, and apoptosis. Tamoxifen Citrate is used to treat breast cancer, sometimes in conjunction with other anticancer drugs. It is also used to reduce the risk of breast cancer in women with a high risk of developing the disease.
|Physical State & Appearance||Liquid (Clear)|
|Storage Requirements||Room Temperature|