Description

The hormone Ghrelin is a growth hormone releasing hexapeptide, which is heavily involved in the regulation of growth hormone. Ghrelin is released from the stomach in response to food consumption, and positively associated with body weight. Ghrelin administration increases appetite, enhances growth hormone secretion, and increases spontaneous physical activity levels.

Ghrelin’s effects are mediated through the growth hormone secretagogue receptor (GHS-R1A), which is found in multiple tissues such as the liver, pancreas, muscle, gut, and adipose tissue. While it is known that growth hormone increases fat loss, it is also known that ghrelin stimulates growth hormone secretion. Therefore, it is of interest to understand the effects of exogenous ghrelin administration, how it interacts with weight loss, and how it has the potential to positively impact clinical outcomes.

MK-677
CAS Number	159634-47-6
Molar Mass	528.67 g·mol−1
Chemical Formula	C14H12F6N2O
IUPAC Name	2-amino-2-methyl-N-[1-(1-methylsulfonylspiro[2H indole-3,4′-piperidine]-1′-yl)-1-oxo-3-phenylmethoxypropan-2-yl]propanamide